Invention of a new cell-scale magnetic separation process

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Invention of a new cell-scale magnetic separation process

The latest news is that a research group at the Shenzhen Institute of Advanced Technology has developed an approach to magnetic separation. In order to certify the reliability of the new process, numerous tests were carried out. Without any major surprises, the results were more than conclusive.

Transfer of information at the cellular level

In fact, the new approach that was developed by these researchers took place on exosomes and is based on the use of high gradient magnetic fields. The magnetic flux thus obtained is then directed to special terminals able to manipulate them to submit them to the cells to be studied.

In addition, the results of the studies have been published in the journal Lab on a Chip. Yang Huia professor at the Shenzhen Institute of Advanced Technology, was one of the contributors to this evolutionary discovery.

High spectrum magnetic flux was the best option

The magnetic dislocation system that was used by the researchers is based on the principle of negative magnetophoresis. Indeed, the central unit controlling this assembly is a unit with an ultra-high gradient magnetic field. This magnetic flux is obtained from permanent magnets as well as on-chip magnetic pole arrays.

Additionally, through the module, the system can create an ultra-high magnetic field in microfluidic channels to sample extraction. Extremely small biological samples can therefore be collected. Moreover, the choice of sizes to distinguish between samples of different sizes is significantly improved over existing techniques.

“By opting for on-chip pole assemblies, the magnetic field gradient in the microchannel is greatly increased. As a result, on-chip magnetophoretic disjunction is performed using a very dilute ferrofluid. »

Dr. ZENG Lin, lead author of this study

Perfecting an already flawless approach for greater success

Following the use of the ferrofluid solution, the scientists wanted to push their exploits even further. For this purpose, a new biocompatible solution, able to simultaneously meet the needs of separating exosomes and maintaining their bioactivity was engineered. Without great surprises, with this biocompatible ferrofluid, the system achieves the disjunction of exosomes by maintaining high reliability.

“The fabricated microfluidic array provides opportunities for studies of exosomes, and treatment of the conditions they cause. »

YANG Hui professor at Shenzhen Institute of Advanced Technology (SIAT)


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